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Functional genomics

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    Functional genomics

    The overall research goals of the research group for Functional Genomics are to employ science-based analyses and solutions to real problems. This involves conducting “basic science with an applied perspective”. Functional Genomics is combining Molecular and Quantitative Genetics, Molecular biology, Metabolome analysis and bioinformatics to elucidate gene- and genome function. The group employ a common range of state-of-the-art technologies to obtain precise knowledge of how single or multiple genes underpin observed phenotypes within a range of organisms. The objects of study are model systems such as Saccharomyces cerevisiae, Escherichia coli, Arabidopsis thaliana, Caenorhabditis elegans, Orchesella cincta, Musca domestica and Drosophila melanogaster, as well as various bacterial communities, potatoes, various species of filamentous fungi and other insects/ectotherms, which are relevant for scientific and technological challenges within natural ecology, evolution, agriculture, engineered systems and human health. Particular expertise in the group exist within long- and short read biological sequence analysis, quantitative and evolutionary genetics, potato biology, age related human diseases and analysis of secondary metabolites.

    Key words: 

    • Molecular and Quantitative Genetics
    • Molecular biology
    • Metabolome analysis
    • Bioinformatics
    • Fungal biotechnology
    • Potato crop biology
    • Insect ecology and physiology
    • Bacterial communities
    • Long- and short read nucleotide sequencing technologies
    • Bioinformatics development
    • Natural ecology
    • Evolution
    • Agriculture
    • Engineered systems
    • Human Health

C. elegans Lab

C. Elegans Lab

C. elegans  tools: mutants, unbiased screening, CRISPR, RNAi, genetics of ageing and age related diseases, C. elegans disease models, probiotics and ageing, role of microbiota in ageing, MRSA infection models: alternatives to antibiotics, host-microbe interactions, stress responses and apoptosis.

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Nanopore sequencing

Method development, microbiology, tree-of-life, real-time analysis, metagenomics, amplicon sequencing, genome-centric metagenomics, visualisation, R
 

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Fungal biotech

Genome mining for biosynthetic gene clusters, elucidation of biosynthetic pathways for secondary metabolites, determination of fungal community in environmental samples, heterologous expression of secondary metabolite biosynthetic gene clusters. 

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Potato biology

Basic potato biology, population genetics of potato, genomics assisted breeding of potato, potato genomics and transcriptomics, predictive modelling, bioinformatics, abiotic stress, innovative disease resistance management in crops.

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    Funding

    The area of Functional genomics is supported by external grants from both national and international funding bodies. We consider external funding a prerequisite to realize research ideas and therefore, the group pursues funding to realize research ideas at all levels. As part of the planned activities of the research group is to discuss ideas for common research projects. This also includes funding possibilities.

    Grants (2013-2019) include:

    The Velux Foundations, Innovation fund Denmark, Kartoffelafgiftsfonden, Obelske Familiefond, The Danish Council for Strategic Research, The Ministry of Food, Agriculture and Fisheries, Aalborg Zoo Conservation Foundation, Carlsbergfondet, Aage V. Jensen Naturfond, Independent Research Fund Denmark (FNU and FTP), Novo Nordic Foundation

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    Collaborations

    We collaborate broadly with both public and private actors of any size at the regional, national and international level.

    As of end of 2018, active collaborations on the regional level exist with the Faculty of Medicine and Aalborg University Hospital, Biotech Innovation and AKV Langholt.  

    At the national scale active collaborations with researchers at Copenhagen University, Aarhus University, Danish Technical University, as well as Danespo, Bioproduction, DuPont and KMC.

    Internationally, we collaborate with researchers all over the world. This includes potato breeding companies in Germany and the Netherlands and multiple universities including Waageningen University (NL), James Hutton Institute (GB) University of Potsdam, (DE), University of Helsinki, (FI),  Norwegian Institute of Bioeconomy Research (NO),  Agriculture and Agrifood Canada (CA), Melbourne University (AU), Monash University (AU), University of Jyväskylä (FI), Lund University (SE),  University of Ljubljana (SI), Doñana Biological Station (ES), Buck Institute (US), Sanford Burnham Prebys Medical Discovery Institute (US), Scripps Research Institute (US).